COVID-19 - The crossroads between immunization and lung failure

Grant number: unknown

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Key facts

  • Disease

    COVID-19
  • start year

    -99
  • Known Financial Commitments (USD)

    $0
  • Funder

    University of São Paulo
  • Principal Investigator

    N/A

  • Research Location

    Brazil
  • Lead Research Institution

    N/A
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The viral infection process is a continuum between invasion, replication, alert, immediate and future defense, and a return to normal condition. The IB's Neuroimmunomodulation and Chronopharmacology Laboratories are currently expanding these studies with biological data obtained from patients and infected with SarsCov2 evaluating the relationship of signaling pathways and cytokine synthesis, adhesion molecules and molecules involved in virus replication with production of melatonin. These studies aim to expand the knowledge of escapes from defense mechanisms and to propose supportive therapies that may be useful at this time and in others where there is an imbalance between defense and attack.