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COVID-Heart. Viral and inflammatory profile in the myocardium of patients infected with SARS-CoV2.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    University of São Paulo

  • Principal Investigator

    N/A

  • Research Location

    Brazil

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

In a Chinese cohort of patients infected with SARS-CoV2, 86% of patients with fatal outcomes had respiratory compromise, and of these, 33% had concomitant cardiac involvement and myocardial injury. Also in this cohort, 7% of patients with fatal outcomes had isolated cardiac injury evolving to cardiogenic shock, thus suggesting a mechanism of primary or secondary myocardial aggression. Cases of fulminant myocarditis have also been described. Viral, immunological and inflammatory aggression was not characterized in myocardial tissue. Patients will undergo functional evaluation (echocardiogram), myocardial injury (electrocardiogram) and biomarkers. Patients who evolve to death will have heart fragments collected for evaluation of viroma (RT-PCR), inflammatory profile (RT-PCR and ELISA) and cellularity (histology and immunohistochemistry).