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Analysis of ACE2 expression in diseases associated with severe COVID19.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    University of São Paulo

  • Principal Investigator

    N/A

  • Research Location

    Brazil

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

To investigate why people with comorbidities such as hypertension and diabetes are more likely to develop severe COVID, we investigated transcriptome data from lung and other tissues from patients with these diseases. The objective was to verify whether the expression of ACE2 and other genes necessary for SARS-CoV-2 virus infection was increased in patients with this disease. We submitted the first article to the Journal of Infectious Diseases and posted it in the repository: https://www.medrxiv.org/content/10.1101/2020.03.21.20040261v1#disqus_thread