Enhanced laboratory support to perform assessment of vaccine effectiveness against SARS-Co-V-2 infection

Grant number: VMVPT21550

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2021
    2022
  • Known Financial Commitments (USD)

    $144,147.37
  • Funder

    Estonian Research Council
  • Principal Investigator

    Unspecified Unspecified Unspecified
  • Research Location

    Estonia
  • Lead Research Institution

    University of Tartu
  • Research Priority Alignment

    N/A
  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    Characterisation of vaccine-induced immunity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Health Personnel

Abstract

In order to assess the shortcomings and strengths of the vaccination plan, it is critical to evaluate the efficacy of the vaccines in normal use (public health practice). The effectiveness of a vaccine in real-world vaccine effectiveness (VE) is affected by a number of factors, including the transport, storage and administration of the vaccine to patients. Young people and healthy people are usually recruited for clinical trials of vaccines, while in real life the vaccine is used primarily by older people and people with chronic diseases. The efficacy of the vaccine in different age and risk groups, the duration of the protective effect, the effectiveness in preventing transmission, the relative effectiveness compared to other vaccines can be evaluated in routine VE studies. relationship to the number and timing of doses administered and efficacy against new strains of SARS-CoV-2. The main aim of the study was to evaluate the effectiveness (CO) of the COVID-19 vaccine in hospital staff. Secondary Objectives: To measure the efficacy (VE) of a product-specific COVID-19 vaccine among hospital staff based on: (i) the number of doses administered; (ii) the time of the last dose; (iii) the age of the employee; (iv) the employee's position and / or department; (v) whether or not the employee has direct contact with patients.