(Theme 2) The role of antibody in COVID-19 disease: distinguishing disease enhancing and prtective immune responses.

The emergence of rare but debilitating conditions associated with SARS-CoV-2 - including Paediatric Inflammatory Multisystem Syndrome (PIMS) or Kawasaki disease (KD) - has raised concern that antibodies may enhance disease. In this project, researchers aim to assess how cross-reactive antibodies against other coronaviruses cause severe disease, how do antibody responses differ between patients with asymptomatic/mild infections and severe disease and how antibodies influence the rest of the immune response.