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(Theme 3) Cause and effect in receptor binding specificity associated with transfer between host species

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-358

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Key facts

  • Disease

    COVID-19

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Steve Gamblin

  • Research Location

    United Kingdom

  • Lead Research Institution

    Francis Crick Institute

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

This study investigates the relationship of spike (S) glycoprotein from SARS-CoV-2 with the S protein of a closely related bat virus, RaTG13. Using a range of structural biology techniques, such as Cryo-EM, to determine how viruses physically differ is invaluable to not only determine how SARS-CoV-2 binds to human ACE2 receptors but how disruption to its structure can destabilise the virus, opening opportunities to identify potential treatments.