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Does COVID-19 affect the brain? Gaining mechanistic insight "in vitro" on how brain cell function is disrupted upon exposure to serum from COVID-19 patients with neurological symptom

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-414

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Key facts

  • Disease

    COVID-19

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Dr. Anthony Vernon, Dr. Deepak Srivastava

  • Research Location

    United Kingdom

  • Lead Research Institution

    MRC Centre for Neurodevelopmental Disorders at King's College London

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

1]: for this study, to serum collected during hospitalization from a cohort of N=36 non-intensive therapy unit (ITU) COVID-19 patients, with and without delirium at admission. We will then identify inflammatory and neurogenic pathways underpinning the effects of the serum on cell proliferation, differentiation and apoptosis, proposing novel therapeutic targets for patients with COVID-19-delirium and possibly with other neurological and cognitive symptoms. Finally, results from this study will inform a planned grant application on neurological and cognitive follow-up of COVID-19-infected patient.