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Genetic architecture of host proteins interacting with SARS-CoV-2 - July 2020

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-503

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Dr. Claudia Langenberg

  • Research Location

    United Kingdom

  • Lead Research Institution

    MRC Epidemiology Unit

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

A team led by Unit researcher Dr Claudia Langenberg has published in Omicscience summary statistics for large-scale genomic and plasma proteomic data from over 10,000 individuals to characterise genetic architecture of host proteins reported to interact with SARS-CoV-2. This accompanies the submission of the paper "Genetic architecture of host proteins interacting with SARS-CoV" which is available on BioRxiv. The summary statistics freely available without restrictions, and include an interactive matrix and annotations for all protein targets and cis-associated genetic loci, as well as interactive tables with pGWAS summary statistics for individual SNPs, genes, or genetic regions from which results can be sorted, filtered, and exported.