Hyperinflammation and immunity in COVID-19

Key facts

Disease
COVID-19
start year
-99
Known Financial Commitments (USD)
$0
Funder
Elizabeth Blackwell Institute for Health Research
Principal Investigator
Laura Rivino
Research Location
United Kingdom
Lead Research Institution
N/A
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

Establishing a robust and safe immunophenotyping methodology. This project aims to establish tools for the in-depth analysis of the activation/functionality of innate and adaptive immune cells in human blood, with the aim of subsequently applying these tools to probe immune cell activation in COVID-19 patients and define immune subsets driving the cytokine storm and biomarkers associated with immunopathology/immune protection.

Publicationslinked via Europe PMC

Last Updated:an hour ago

View all publications at Europe PMC

Role of voltage-gated Ca²⁺ channel dysfunction in gastric vagal afferent neuropathy following spinal cord injury.

Outcomes in pregnant patients with congenital heart disease by rurality.

Autophagy activator AA-20 improves proteostasis and extends <i>Caenorhabditis elegans</i> lifespan.

Islet environment and development of type 1 diabetes in the biobreeding rat model.

β-Cell Function Derived From Routine Clinical Measures Reports and Predicts Treatment Response to Immunotherapy in Recent-Onset Type 1 Diabetes.

Targeting Tmem63b and Piezo2 in C-fiber low threshold mechanoreceptor: limitation of Vglut3-IRES-Cre

The association between adverse childhood experiences and mental disorders among adolescents in Kenya, Indonesia, and Vietnam: Evidence from the National Adolescent Mental Health Surveys.

Brain biomechanics governs mitotic fidelity of embryonic neural progenitors

T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma.