The OpenSafely Research Platform

Grant number: 222097/Z/20/Z

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2023
  • Known Financial Commitments (USD)

    $3,002,509.66
  • Funder

    Wellcome Trust
  • Principal Investigator

    Dr. Ben Goldacre
  • Research Location

    United Kingdom
  • Lead Research Institution

    University of Oxford
  • Research Priority Alignment

    N/A
  • Research Category

    Health Systems Research

  • Research Subcategory

    Health information systems

  • Special Interest Tags

    Data Management and Data Sharing

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

OpenSAFELY is a new secure analytics platform for electronic health records in the NHS, created to deliver urgent results during the global COVID-19 emergency. It is now successfully delivering analyses across more than 24 million patients' full pseudonymised primary care NHS records, with more to follow shortly. All our analytic software is open for security review, scientific review, and re-use. OpenSAFELY uses a new model for enhanced security and timely access to data: we don't transport large volumes of potentially disclosive pseudonymised patient data outside of the secure environments managed by the electronic health record software company; instead, trusted analysts can run large scale computation across live pseudonymised patient records inside the data centre of the electronic health records software company. This pragmatic and secure approach has allowed us to deliver our first analyses in just five weeks from project start.

Publicationslinked via Europe PMC

Recording of Pharmacy First consultations in general practice records in England: an observational study of the service’s first year using OpenSAFELY

Tocilizumab versus sarilumab among adults hospitalised with COVID-19: target trial emulation across England and Scotland

Time trends in new diagnoses of 19 long-term conditions: a population-level cohort study in England using OpenSAFELY

Long-term kidney outcomes after COVID-19: a matched cohort study using the OpenSAFELY platform.

Effect of the 2022 COVID-19 booster vaccination campaign in people aged 50 years in England: Regression discontinuity analysis in OpenSAFELY-TPP.

Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenSAFELY-TPP.

Opioid prescribing to people on orthopaedic waiting lists during the COVID-19 pandemic in England: a study using OpenSAFELY-TPP

Healthcare use in individuals with rheumatoid arthritis during the COVID-19 pandemic and beyond: A cohort study in three nations of the UK

Uptake of service specific codes for the COVID oximetry @Home Pulse Oximetry service: an analysis of 57 million patients’ primary care records using OpenSAFELY