Cold atmospheric plasma deactivation potential for viruses and bacteria in respiratory aerosol droplets
- Funded by German Research Foundation (DFG)
- Total publications:0 publications
Grant number: 511873613
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Key facts
Disease
COVID-19start year
2022Funder
German Research Foundation (DFG)Principal Investigator
Prof. Nina MerkertResearch Location
GermanyLead Research Institution
Technical University of ClausthalResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen genomics, mutations and adaptations
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The use of cold atmospheric plasmas has attracted a lot of attention in recent years and has already found numerous biomedical applications. The Covid-19 pandemic has increased the demand for inactivating viruses in aerosol particles. Atomistic simulations can provide fundamental insights into this process. However, the study of ions and vibrationally excited molecules requires further investigation. Most biological organisms, including the corona virus, are surrounded by a liquid film. Therefore, it is necessary to understand which interactions between the plasma and the liquid take place before the plasma species reach the surface of the bio-organism. To get a better understanding of this behavior, we will combine experimental aerosol measurements with molecular dynamics (MD) simulations to study the chemical reactions between gaseous oxygen and nitrogen species and water molecules. We will answer the research question of whether the charged species generated in the plasma recombine before reaching the virus. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. to study the chemical reactions between gaseous oxygen and nitrogen species and water molecules. We will answer the research question of whether the charged species generated in the plasma recombine before reaching the virus. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. to study the chemical reactions between gaseous oxygen and nitrogen species and water molecules. We will answer the research question of whether the charged species generated in the plasma recombine before reaching the virus. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account.