Cold atmospheric plasma deactivation potential for viruses and bacteria in respiratory aerosol droplets

  • Funded by German Research Foundation (DFG)
  • Total publications:0 publications

Grant number: 511873613

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Key facts

  • Disease

    COVID-19
  • start year

    2022
  • Funder

    German Research Foundation (DFG)
  • Principal Investigator

    Prof. Nina Merkert
  • Research Location

    Germany
  • Lead Research Institution

    Technical University of Clausthal
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The use of cold atmospheric plasmas has attracted a lot of attention in recent years and has already found numerous biomedical applications. The Covid-19 pandemic has increased the demand for inactivating viruses in aerosol particles. Atomistic simulations can provide fundamental insights into this process. However, the study of ions and vibrationally excited molecules requires further investigation. Most biological organisms, including the corona virus, are surrounded by a liquid film. Therefore, it is necessary to understand which interactions between the plasma and the liquid take place before the plasma species reach the surface of the bio-organism. To get a better understanding of this behavior, we will combine experimental aerosol measurements with molecular dynamics (MD) simulations to study the chemical reactions between gaseous oxygen and nitrogen species and water molecules. We will answer the research question of whether the charged species generated in the plasma recombine before reaching the virus. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. to study the chemical reactions between gaseous oxygen and nitrogen species and water molecules. We will answer the research question of whether the charged species generated in the plasma recombine before reaching the virus. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. to study the chemical reactions between gaseous oxygen and nitrogen species and water molecules. We will answer the research question of whether the charged species generated in the plasma recombine before reaching the virus. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account. We will study the effects of reactive plasma species on the structure of spike (S)-glycoprotein, which plays a key role in coronavirus pathogenicity, transmission and evolution. The aim of the project is to find ideal process conditions for plasma disinfection, taking liquid layers into account.