MRC Centre for Global Infectious Disease Analysis (MRC GIDA)

Grant number: MR/X020258/1

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Key facts

  • Disease

    Disease X
  • Start & end year

    2023
    2026
  • Known Financial Commitments (USD)

    $3,659,554.08
  • Funder

    UK Research and Innovation (UKRI)
  • Principal Investigator

    Professor Azra Ghani
  • Research Location

    United Kingdom
  • Lead Research Institution

    Imperial College London
  • Research Priority Alignment

    N/A
  • Research Category

    Epidemiological studies

  • Research Subcategory

    N/A

  • Special Interest Tags

    Data Management and Data Sharing

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The COVID-19 pandemic has highlighted the threat that infectious diseases pose to societies whilst the rapid global spread of monkeypox, the identification of polio in the UK and US, and the emergence of Marburg viral haemorrhagic fever in Ghana are timely reminders of the challenges that lay ahead. Over the last 15 years, the MRC Centre for Global Infectious Disease Analysis has been at the forefront of the development and application of data analysis and modelling across a wide range of pathogens. A key feature of our approach is our close links with public health agencies in the UK and internationally, enabling rapid translation of scientific insights into actionable public health support. During this award, we aim to catalyse our inter-disciplinary approach across four research-based themes: a) Preparedness and Response to Emerging Threats: Building the epidemiological tools required nationally and internationally to respond to new threats. b) Global Health Analytics: Supporting strategies to control and eliminate endemic diseases. c) Vaccines and Therapeutics: Supporting the development pipeline for new products and evaluating the retrospective and prospective impact of existing products in reducing disease burden. d) Pathogen Genomic Epidemiology: Developing genomics data to support better surveillance of emerging threats and to inform vaccine development, alongside analytical methods that integrate genomic and epidemiological data to inform public health policy. Through three underpinning pillars - research software engineering, translation and communication (including a dedicated Translational Modelling Hub) and training and capacity strengthening - we will enable rapid communication and uptake of our outputs to external partners - including the academic community, public health agencies and wider society.

Publicationslinked via Europe PMC

HISTONCHO: A dataset of intervention histories for onchocerciasis control & elimination in sub-Saharan Africa.

Early individualized risk prediction using clinical data for children during the febrile phase of dengue in outpatient settings in Vietnam and Thailand.

Appraising the HIV prevention cascade methodology to improve HIV prevention targets: Lessons learned from a general population pilot study in east Zimbabwe.

The economic burden of dengue: a systematic literature review of unit costs for non-fatal episodes treated in the formal healthcare system.

Modelling the effects of immigration on the re-introduction of onchocerciasis.

Comparison of the sensitivity of targeted and untargeted (metagenomic) methods for the detection of viral pathogens in wastewater.

Social mixing and time use throughout the year: Potential changes in disease transmission and age distribution of cases.

Why are gonorrhea case rates declining in the US? A research agenda.

Fast and trustworthy nowcasting of dengue fever: A case study using attention-based probabilistic neural networks in São Paulo, Brazil.