MRC Centre for Global Infectious Disease Analysis (MRC GIDA)

Grant number: MR/X020258/1

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Key facts

  • Disease

    Disease X
  • Start & end year

    2023
    2026
  • Known Financial Commitments (USD)

    $3,659,554.08
  • Funder

    UK Research and Innovation (UKRI)
  • Principal Investigator

    Professor Azra Ghani
  • Research Location

    United Kingdom
  • Lead Research Institution

    Imperial College London
  • Research Priority Alignment

    N/A
  • Research Category

    Epidemiological studies
  • Research Subcategory

    N/A
  • Special Interest Tags

    Data Management and Data Sharing
  • Study Type

    Non-Clinical
  • Clinical Trial Details

    N/A
  • Broad Policy Alignment

    Pending
  • Age Group

    Not Applicable
  • Vulnerable Population

    Not applicable
  • Occupations of Interest

    Not applicable

Abstract

The COVID-19 pandemic has highlighted the threat that infectious diseases pose to societies whilst the rapid global spread of monkeypox, the identification of polio in the UK and US, and the emergence of Marburg viral haemorrhagic fever in Ghana are timely reminders of the challenges that lay ahead. Over the last 15 years, the MRC Centre for Global Infectious Disease Analysis has been at the forefront of the development and application of data analysis and modelling across a wide range of pathogens. A key feature of our approach is our close links with public health agencies in the UK and internationally, enabling rapid translation of scientific insights into actionable public health support. During this award, we aim to catalyse our inter-disciplinary approach across four research-based themes: a) Preparedness and Response to Emerging Threats: Building the epidemiological tools required nationally and internationally to respond to new threats. b) Global Health Analytics: Supporting strategies to control and eliminate endemic diseases. c) Vaccines and Therapeutics: Supporting the development pipeline for new products and evaluating the retrospective and prospective impact of existing products in reducing disease burden. d) Pathogen Genomic Epidemiology: Developing genomics data to support better surveillance of emerging threats and to inform vaccine development, alongside analytical methods that integrate genomic and epidemiological data to inform public health policy. Through three underpinning pillars - research software engineering, translation and communication (including a dedicated Translational Modelling Hub) and training and capacity strengthening - we will enable rapid communication and uptake of our outputs to external partners - including the academic community, public health agencies and wider society.

264 Publications linked via Europe PMC

HIV diagnosis and treatment status in individuals dying from HIV in Zimbabwe, Malawi, and South Africa: A model comparison analysis.

Declining Onchocerca volvulus transmission despite limited ivermectin delivery in the Kakoi-Koda focus, Ituri, Democratic Republic of the Congo: An epidemiological, entomological and landscape evidence synthesis.

Overall and serotype-specific dengue virus transmission intensity in Mexico, 2016-2023: A modelling study of case-notification data.

Untangling the effects of within-host and between-host natural selection in viruses with applications to evolution of HIV-1 co-receptor usage.

malariasimple: An R package for fast simulations of malaria transmission.

Health impacts of expanding the health workforce across cadres under an incremental budget in Malawi.

A comprehensive AMR genotype-phenotype database (CABBAGE).

Spatial and temporal associations between animal ownership and malaria prevalence in Africa using cross-sectional national Demographic and Health Surveys.

Yellow fever outbreak potential in Djibouti, Somalia and Yemen: a mathematical modelling study.