Return to homepagePandemic Pact

Modeling of congenital disease caused by the Zika Virus in the CNS in 2D/3D models: the initial objective, in addition to the Zika Virus, was expanded to study aspects related to the SARS-COV-2 Coronavirus

  • Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Total publications:0 publications

Grant number: 21/04914-3

Grant search

Key facts

  • Disease

    COVID-19, Zika virus disease

  • Start & end year

    2021
    2023

  • Funder

    Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)

  • Principal Investigator

    Unspecified Unspecified Unspecified

  • Research Location

    Brazil

  • Lead Research Institution

    Centro de Inovação da USP (INOVA). Universidade de São Paulo (USP)

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The mechanisms involved in the pathogenesis of ZIKV and SARS-COV-2 in the CNS will be evaluated using 2D models of human cells and 3D brain organoids derived from iPSC. The study will also involve the use of in vivo models to validate prevention (vaccines) and treatment (drug) strategies. (AU)