LASCOPE extension

The “Lassa fever Clinical Course and Prognostic factors (LASCOPE)” project is a prospective cohort study of patients with acute symptomatic Lassa fever (LF) hospitalized in dedicated treatment centers in Nigeria. The patients have access, free of charge, to reliable molecular diagnosis of LF, ribavirin therapy and an improved standard of supportive care including renal replacement therapy. This study aims at producing up to date data on LF disease presentation and course, management, outcomes and factors associated to fatality. The data produced by the LASCOPE study will inform the design of future trials evaluating innovative therapeutic strategies for LF, as well as the development of updated guidelines for the management of patients with LF. Lastly, this project will contribute to the development of clinical research capacities in the participating sites and put them in position to conduct future therapeutic and vaccine trials for LF.