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AFFINITY REAGENTS FOR THE IMMUNE SYSTEM OF GUINEA PIGS

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 75N93020C00025-0-9999-1

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Key facts

  • Disease

    Ebola, Zika virus disease

  • Start & end year

    2020
    2021

  • Known Financial Commitments (USD)

    $300,000

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    HONG QI

  • Research Location

    United States of America

  • Lead Research Institution

    QOOLABS, INC.

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

To address the need of monoclonal antibodies (MAbs) targeting guinea pig cytokines, the Offeror proposes to generate antibody reagents for Th1 and Th2 cytokines. They will express guinea pig recombinant cytokines in vitro, generate rabbit MAbs for each selected cytokine using their established novel technology, produce and verify rabbit MAbs. The availability of these high affinity MAbs to guinea pig Th1 and Th2 cytokines will facilitate the immunological analysis using this animal model in the field of infectious diseases including studies in tuberculosis, zika viral infection, Ebola and influenza