Human Cells and Tissues Core: 3D Models of Engineered Human iPS Cells to Investigate Neurotropic Virus Infections
- Funded by National Institutes of Health (NIH)
- Total publications:0 publications
Grant number: 5U19AI131135-04
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Key facts
Disease
Zika virus disease, Congenital Zika virus diseasestart year
2020Known Financial Commitments (USD)
$172,269Funder
National Institutes of Health (NIH)Principal Investigator
PROF HEALTH SCIENCES Lee GehrkeResearch Location
United States of AmericaLead Research Institution
MASSACHUSETTS INSTITUTE OF TECHNOLOGYResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
TheÃ' MITÃ' CenterÃ' forÃ' HumanÃ' TissueÃ' ModelsÃ' ofÃ' InfectiousÃ' DiseasesÃ' (MIT.HTMID)Ã' willÃ' studyÃ' viralÃ' infectionsÃ' ofÃ' fiveÃ' typesÃ' ofÃ' neuralÃ' cellsÃ' thatÃ' areÃ' differentiatedÃ' fromÃ' humanÃ' embryonicÃ' stemÃ' (ES)Ã' cellsÃ' orÃ' humanÃ' inducedÃ' pluripotentÃ' stemÃ' (iPS)Ã' cells.Ã' InÃ' addition,Ã' MIT.HTMIDÃ' researchÃ' willÃ' addressÃ' viralÃ' infectionsÃ' ofÃ' humanÃ' threeÃ' dimensionalÃ' (3D)Ã' cerebralÃ' organoidsÃ' towardÃ' understandingÃ' ZikaÃ' virusÃ' microcephaly.Ã' AllÃ' cellÃ' workÃ' andÃ' tissueÃ' workÃ' forÃ' theÃ' Center’sÃ' researchÃ' willÃ' beÃ' supportedÃ' byÃ' theÃ' HumanÃ' CellsÃ' andÃ' TissuesÃ' CoreÃ' facility.Ã' TheÃ' CoreÃ' willÃ' beÃ' locatedÃ' atÃ' theÃ' WhiteheadÃ' Institute,Ã' andÃ' willÃ' provideÃ' aÃ' continuousÃ' supplyÃ' ofÃ' cellsÃ' forÃ' bothÃ' HT.MIDÃ' researchÃ' projects.Ã' ToÃ' prepareÃ' cellsÃ' andÃ' organoidsÃ' fromÃ' iPSÃ' cells,Ã' hâ€Â