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Human Cells and Tissues Core: 3D Models of Engineered Human iPS Cells to Investigate Neurotropic Virus Infections

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 5U19AI131135-04

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Key facts

  • Disease

    Zika virus disease, Congenital infection caused by Zika virus

  • Start & end year

    2020

  • Known Financial Commitments (USD)

    $172,269

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    PROF HEALTH SCIENCES Lee Gehrke

  • Research Location

    United States of America

  • Lead Research Institution

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

TheÃ' MITÃ' CenterÃ' forÃ' HumanÃ' TissueÃ' ModelsÃ' ofÃ' InfectiousÃ' DiseasesÃ' (MIT.HTMID)Ã' willÃ' studyÃ' viralÃ' infectionsÃ' ofÃ' fiveÃ'  typesÃ' ofÃ' neuralÃ' cellsÃ' thatÃ' areÃ' differentiatedÃ' fromÃ' humanÃ' embryonicÃ' stemÃ' (ES)Ã' cellsÃ' orÃ' humanÃ' inducedÃ'  pluripotentÃ' stemÃ' (iPS)Ã' cells.Ã' InÃ' addition,Ã' MIT.HTMIDÃ' researchÃ' willÃ' addressÃ' viralÃ' infectionsÃ' ofÃ' humanÃ' threeÃ'  dimensionalÃ' (3D)Ã' cerebralÃ' organoidsÃ' towardÃ' understandingÃ' ZikaÃ' virusÃ' microcephaly.Ã' AllÃ' cellÃ' workÃ' andÃ' tissueÃ'  workÃ' forÃ' theÃ' Center’sÃ' researchÃ' willÃ' beÃ' supportedÃ' byÃ' theÃ' HumanÃ' CellsÃ' andÃ' TissuesÃ' CoreÃ' facility.Ã' TheÃ' CoreÃ' willÃ'  beÃ' locatedÃ' atÃ' theÃ' WhiteheadÃ' Institute,Ã' andÃ' willÃ' provideÃ' aÃ' continuousÃ' supplyÃ' ofÃ' cellsÃ' forÃ' bothÃ' HT.MIDÃ' researchÃ'  projects.Ã' ToÃ' prepareÃ' cellsÃ' andÃ' organoidsÃ' fromÃ' iPSÃ' cells,Ã' hâ€Â