Optimal use of hospital resources and intervention using suPAR for improving prognosis and care for patients with COVID-19

Grant number: 961844

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $1,044,288.2
  • Funder

    European Commission
  • Principal Investigator

    EUGEN-OLSEN Jesper
  • Research Location

    Denmark
  • Lead Research Institution

    VIROGATES AS
  • Research Priority Alignment

    N/A
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    Innovation

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Optimal use of hospital resources and intervention using suPAR for improving prognosis and care for patients with COVID-19 To optimize hospital resources, it is necessary to test which patients that can be sent home (mild outcome of infection) and which patients that should be admitted to hospital (high risk patients). This will deliver on the tasks: 1) Identify patients that can safely cope with the infection at home and 2) Identify high risk patients early in the disease and 3) Select high-risk patients that may benefit of therapy. But how can we identify low- or high-risk patients? The suPARnostic test developed by ViroGates and CE/IVD approved for clinical use is highly prognostic marker for 30-day mortality. Some hospitals have suPAR in routine clinical assessment of patient risk, and preliminary data support that suPAR levels can triage whether patients with COVID-19 will have a mild or a severe outcome of COVID-19 and thereby select which patients that could be discharged or admitted. We aim to transfer manufacturing, upscale and implement the suPARnostic technology across hospitals in Europe to improve the risk stratification of COVID-19 patients and optimize hospital resources. We furthermore provide a test method that can identify high-risk patients that may benefit from experimental therapeutic interventions that may impact on outcome. The identification of patients in high risk of mortality (patients with high suPAR) provide a possibility to intervene.

Publicationslinked via Europe PMC

Last Updated:43 minutes ago

View all publications at Europe PMC

Calprotectin and Imbalances between Acute-Phase Mediators Are Associated with Critical Illness in COVID-19.