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Delivering a Unified Research Alliance of Biomedical and public health Laboratories against Epidemics

Grant number: 101102733

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Key facts

  • Disease

    Disease X
  • Start & end year

    2023
    2027
  • Known Financial Commitments (USD)

    $27,217,623.73
  • Funder

    European Commission
  • Principal Investigator

    MANUGUERRA Jean-Claude
  • Research Location

    France
  • Lead Research Institution

    INSTITUT PASTEUR
  • Research Priority Alignment

    N/A
  • Research Category

    13

  • Research Subcategory

    N/A

  • Special Interest Tags

    Data Management and Data Sharing

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Outbreaks of infectious diseases are increasing due to multiple local and global interaction changes disrupting the fragile balance of the complex human-animal-environment ecosystem. The increased frequency and complexity of health threats require a different, unified form of preparedness and a coordinated, fast, reliable and effective emergency response. DURABLE is a tailored solution to this recognised need - a strong network of world-class basic and translational research institutes and public health centres across Europe with an outstanding track record in public health support with global reach. DURABLE aims to provide high-quality scientific information in record time to support HERA's decision-making in preparing for and responding to cross-border health threats and assessing the impact of countermeasures. DURABLE will coordinate a global collaboration, from pathogen detection, evolutionary analysis and threat characterisation, with One Health approach, to data and information collection and sharing, for optimal threat response. DURABLE is a unique multidisciplinary consortium with complementary expertise to meet this challenge and build productive interactions with HERA and other stakeholders. Due to their outstanding track record and experience in the field, the DURABLE consortium is competent from day one. DURABLE will develop and validate a roadmap for rapid deployment of key countermeasures, test the robustness of the network, and assess key aspects of its emergency mode when simulating or dealing with identified threats. Additionally, DURABLE will focus on long-term sustainability by focusing on capacity building, training the next generation of researchers and developing pandemic preparedness training modules for the network and beyond. Ultimately, DURABLE will be a one-stop shop for diagnostics, research, preparedness and response to current and future health threats for the benefit of citizens in the EU and worldwide.

47 Publications linked via Europe PMC

Further characterization of infection mechanisms and transmission dynamics of rustrela virus in rodent in vivo models.

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses.

Predictive triage for testing may improve control of a COVID-19 epidemic while reducing testing requirements.

Evolutionary history of Jamestown Canyon virus reveals complex multi-vector ecology.

Live-cell single-vRNP imaging identifies viral gene expression signatures that shape influenza infection heterogeneity.

Relevance of potential endocytosis motifs in Cedar virus glycoprotein G for its biological activity.

Characterisation of immune responses targeting highly pathogenic avian influenza A(H5) viruses in health-care workers in the Netherlands: an observational, cross-sectional analysis.

Tensor cores unlock efficient and lower-energy massive parallelization on phylogenetic trees.

Epidemiology and genomic features of MERS coronavirus in Africa: a systematic and meta-analysis review.