Delivering a Unified Research Alliance of Biomedical and public health Laboratories against Epidemics

Grant number: 101102733

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Key facts

  • Disease

    Disease X
  • Start & end year

    2023
    2027
  • Known Financial Commitments (USD)

    $27,217,623.73
  • Funder

    European Commission
  • Principal Investigator

    MANUGUERRA Jean-Claude
  • Research Location

    France
  • Lead Research Institution

    INSTITUT PASTEUR
  • Research Priority Alignment

    N/A
  • Research Category

    13

  • Research Subcategory

    N/A

  • Special Interest Tags

    Data Management and Data Sharing

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Outbreaks of infectious diseases are increasing due to multiple local and global interaction changes disrupting the fragile balance of the complex human-animal-environment ecosystem. The increased frequency and complexity of health threats require a different, unified form of preparedness and a coordinated, fast, reliable and effective emergency response. DURABLE is a tailored solution to this recognised need - a strong network of world-class basic and translational research institutes and public health centres across Europe with an outstanding track record in public health support with global reach. DURABLE aims to provide high-quality scientific information in record time to support HERA's decision-making in preparing for and responding to cross-border health threats and assessing the impact of countermeasures. DURABLE will coordinate a global collaboration, from pathogen detection, evolutionary analysis and threat characterisation, with One Health approach, to data and information collection and sharing, for optimal threat response. DURABLE is a unique multidisciplinary consortium with complementary expertise to meet this challenge and build productive interactions with HERA and other stakeholders. Due to their outstanding track record and experience in the field, the DURABLE consortium is competent from day one. DURABLE will develop and validate a roadmap for rapid deployment of key countermeasures, test the robustness of the network, and assess key aspects of its emergency mode when simulating or dealing with identified threats. Additionally, DURABLE will focus on long-term sustainability by focusing on capacity building, training the next generation of researchers and developing pandemic preparedness training modules for the network and beyond. Ultimately, DURABLE will be a one-stop shop for diagnostics, research, preparedness and response to current and future health threats for the benefit of citizens in the EU and worldwide.

Publicationslinked via Europe PMC

Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks.

Isolation of Human Metapneumovirus from clinical specimen in human organoid-derived bronchial cell cultures is superior to isolation in monolayer cell line cultures.

Dengue and Oropouche virus co-infection in a traveller from Cuba to Portugal.

Developing molecular surveillance of SARS-CoV-2 in the Czech Republic (2021-2022).

Trends Towards Enhanced Rates and Sex Parity in HPV Vaccination in Croatia (2016-2023).

The role of M2 proteins of pneumoviruses in transcription regulation, prevention of hypermutation, and activation of the type I interferon pathway.

Seroprevalence of Toscana virus in blood donors in mainland Portugal.

A Global Collaborative Comparison of SARS-CoV-2 Antigenicity Across 15 Laboratories.

Highly Pathogenic Avian Influenza (HPAI) H5N1 virus in Finland in 2021-2023 - Genetic diversity of the viruses and infection kinetics in human dendritic cells.