to assess the effects of mitochondrial DNA (mtDNA) haplogroups on SARS-CoV-2 sensitivity

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Key facts

Disease
COVID-19
Start & end year
2022
Known Financial Commitments (USD)
$2,324,617
Funder
Gates Foundation
Research Location
United States of America
Lead Research Institution
Children's Hospital of Philadelphia
Research Priority Alignment
N/A

Research Category
Clinical characterisation and management
Research Subcategory
Disease pathogenesis
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

N/A

6 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Mitochondrial OXPHOS restricts SARS-CoV-2 replication.

Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis.

Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

Authors
Topper MJ, Guarnieri JW, Haltom JA, Chadburn A, Cope H, Frere J, An J, Borczuk A, Sinha S, Kim J, Park J, Butler D, Meydan C, Foox J, Bram Y, Richard SA, Epsi NJ, Agan B, Chenoweth JG, Simons MP, Tribble D, Burgess T, Dalgard C, Heise MT, Moorman NJ, Baxter VK, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Beigel K, Widjaja GA, Janssen KA, Lie T, Murdock DG, Angelin A, Soto Albrecht YE, Olali AZ, Cen Z, Dybas J, Priebe W, Emmett MR, Best SM, Kelsey Johnson M, Trovao NS, Clark KB, Zaksas V, Meller R, Grabham P, Schisler JC, Moraes-Vieira PM, Pollett S, Mason CE, Syrkin Wurtele E, Taylor D, Schwartz RE, Beheshti A, Wallace DC, Baylin SB.
Publish Year
2024
Journal
Proceedings of the National Academy of Sciences of the United States of America
DOI
10.1073/pnas.2401968121

View at Europe PMC

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to assess the effects of mitochondrial DNA (mtDNA) haplogroups on SARS-CoV-2 sensitivity

Key facts

Abstract

6 Publications linked via Europe PMC

Mitochondrial OXPHOS restricts SARS-CoV-2 replication.

Authors

Publish Year

Journal

DOI

Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis.

Authors

Publish Year

Journal

DOI

Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

Authors

Publish Year

Journal

DOI

PET Imaging with [¹⁸F]ROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice.

Authors

Publish Year

Journal

DOI

Mitochondrial antioxidants abate SARS-COV-2 pathology in mice.

Authors

Publish Year

Journal

DOI

SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19.

Authors

Publish Year

Journal

DOI

to assess the effects of mitochondrial DNA (mtDNA) haplogroups on SARS-CoV-2 sensitivity

Key facts

Abstract

6 Publications linked via Europe PMC

Mitochondrial OXPHOS restricts SARS-CoV-2 replication.

Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis.

Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

PET Imaging with [18F]ROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice.

Mitochondrial antioxidants abate SARS-COV-2 pathology in mice.

SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19.

PET Imaging with [¹⁸F]ROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice.