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to determine the mechanism of SARS-CoV-2 antiviral activity of repurposed compounds in human lung organoids

Grant number: INV-037420

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2021

  • Known Financial Commitments (USD)

    $164,543

  • Funder

    Gates Foundation

  • Research Location

    United States of America

  • Lead Research Institution

    Joan & Sanford I. Weill Medical College of Cornell University

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    Innovation

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

N/A

4 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection.

Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection.

SARS-CoV-2 infection causes dopaminergic neuron senescence.

A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection.