to establish animal models for COVID-19 infection, to define the pathogenesis and immunology of infection, and to utilize these models to test vaccines and/or therapeutics

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Key facts

Disease
COVID-19
Start & end year
2020
Known Financial Commitments (USD)
$4,352,365
Funder
Gates Foundation
Research Location
United States of America
Lead Research Institution
Beth Israel Deaconess Medical Center Inc.
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

N/A

5 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.

Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.

Authors
Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Brunette N, Wang JY, Walkey C, Fiala B, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC.
Publish Year
2021
Journal
Proceedings of the National Academy of Sciences of the United States of America
DOI
10.1073/pnas.2106845118

View at Europe PMC

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.

Authors
Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, Ali V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH.
Publish Year
2020
Journal
Nature medicine
DOI
10.1038/s41591-020-1070-6

View at Europe PMC

SARS-CoV-2 infection protects against rechallenge in rhesus macaques.

Authors
Chandrashekar A, Liu J, Martinot AJ, McMahan K, Mercado NB, Peter L, Tostanoski LH, Yu J, Maliga Z, Nekorchuk M, Busman-Sahay K, Terry M, Wrijil LM, Ducat S, Martinez DR, Atyeo C, Fischinger S, Burke JS, Slein MD, Pessaint L, Van Ry A, Greenhouse J, Taylor T, Blade K, Cook A, Finneyfrock B, Brown R, Teow E, Velasco J, Zahn R, Wegmann F, Abbink P, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kordana N, Li Z, Lifton MA, Mahrokhian SH, Maxfield LF, Nityanandam R, Nkolola JP, Schmidt AG, Miller AD, Baric RS, Alter G, Sorger PK, Estes JD, Andersen H, Lewis MG, Barouch DH.
Publish Year
2020
Journal
Science (New York, N.Y.)
DOI
10.1126/science.abc4776

View at Europe PMC

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to establish animal models for COVID-19 infection, to define the pathogenesis and immunology of infection, and to utilize these models to test vaccines and/or therapeutics

Key facts

Abstract

5 Publications linked via Europe PMC

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.

Authors

Publish Year

Journal

DOI

Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.

Authors

Publish Year

Journal

DOI

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.

Authors

Publish Year

Journal

DOI

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.

Authors

Publish Year

Journal

DOI

SARS-CoV-2 infection protects against rechallenge in rhesus macaques.

Authors

Publish Year

Journal

DOI