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UKRI: SARS-Cov-2 infection at the animal-human interface: longevity and re-infection dynamics with virus evolution. - SE0563

  • Funded by Department for Environment, Food and Rural Affairs (DEFRA)
  • Total publications:0 publications

Grant number: SE0563

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2021
    2023

  • Known Financial Commitments (USD)

    $803,810.32

  • Funder

    Department for Environment, Food and Rural Affairs (DEFRA)

  • Principal Investigator

    N/A

  • Research Location

    United Kingdom

  • Lead Research Institution

    APHA (Animal and Plant Health Agency)

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Aims: A. To assess virological parameters in longitudinal infection including delineating between 'Äòinfected'Äô (virus genome) and 'Äòinfectious'Äô (viable/transmissible virus) during the course of infection. B. Investigate the longevity of SARS-CoV-2 immunity in SARS-CoV-2 infection and re-infection with human and 'Äòanimal-like'Äô SARS-CoV-2 virus variants. C. To assess the potential for re-infection with SARS-CoV-2 and assess the parameters around virus kinetics human and 'Äòanimal-like'Äô SARS-CoV-2 virus variants. D. Investigate how genetically different virus variants alter the potential or parameters in re-infection. E. Investigate the role of re-infection in onward transmission with human and 'Äòanimal-like'Äô SARS-CoV-2 virus variants. F. To characterise the effect of natural immunity on virus evolution with human and 'Äòanimal-like'Äô SARS-CoV-2 virus variants.