Clover - COVID-19

- CEPI commits up to an additional US$36.9 million for a total investment of up to $397.4 million to support the development of Clover's COVID-19 vaccine candidate, SCB-2019 (CpG 1018/Alum) -CEPI funding supports development of SCB-2019 (CpG 1018/Alum) for primary vaccination across all age groups (pediatric, adolescent, adults, and elderly) and development as a potential booster CHENGDU, China, and OSLO, Norway, November 18, 2021 'Äî Clover Biopharmaceuticals, Ltd. (Clover; Stock code: 2197.HK), a global clinical-stage biotechnology company committed to developing novel vaccines and biologic therapeutic candidates, and CEPI, the Coalition for Epidemic Preparedness Innovations, today announced that CEPI will provide up to an additional US$36.9 million in funding to support continued development of SCB-2019 (CpG 1018/Alum) through licensure. This brings CEPI's total potential funding in SCB-2019 (CpG 1018/Alum) up to US$397.4 million, which represents one of CEPI's largest investments in a COVID-19 vaccine manufacturer to date. Previous CEPI funding has supported preclinical and clinical testing of the vaccine, in addition to scaling up the manufacturing process. Pending WHO Emergency Use Listing (EUL), Clover will supply up to 414 million doses of the vaccine to the COVAX Facility for equitable distribution. Clover is utilizing the funding from CEPI to develop SCB-2019 (CpG 1018/Alum) as a primary vaccination for all age groups (pediatric, adolescent, adults and elderly) and as a potential booster for previously-infected individuals and populations that have received SCB-2019 (CpG 1018/Alum) for the primary vaccination (homologous booster). In September 2021, Clover announced SPECTRA, a global pivotal phase 2/3 clinical trial evaluating the efficacy, safety, and immunogenicity of SCB-2019 (CpG 1018/Alum), met the primary and secondary endpoints and that a single dose of SCB-2019 (CpG 1018/Alum) in individuals who had previously been infected by SARS-CoV-2 induced a rapid and strong boosting effect on neutralizing antibody titers [1]. Evaluation of SCB-2019 (CpG 1018/Alum) as a homologous booster will be conducted as an expansion arm of SPECTRA and initiate in the near-term. Clover is also in the process of planning multiple heterologous booster studies with SCB-2019 (CpG 1018/Alum).