COVID-Protect - Efficacy of Nrf2 activators for the prevention of cell damage in COVID-19 - Toxicity and efficacy studies subproject.

  • Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Total publications:5 publications

Grant number: 01KI20143C

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $292,391.27
  • Funder

    Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Principal Investigator

    N/A

  • Research Location

    Germany
  • Lead Research Institution

    Helmholtz-Zentrum für Infektionsforschung GmbH
  • Research Priority Alignment

    N/A
  • Research Category

    Infection prevention and control

  • Research Subcategory

    IPC in health care settings

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Health Personnel

Abstract

COVID-19 poses a great challenge for humanity and the health system whose functionality is of great importance. Due to the rapid spread of COVID-19, protective measures are essential. Healthcare workers are at forefront of exposure to infected and undiagnosed COVID-19 cases. Regardless of the pandemic, patients, especially the chronic ill, need medical advice. In this case, protection of employees in health care system is linked to specific requirements to avoid contagion and staff downtime and to ensure the functionality of the basic health care system. Recommendations for personal protective equipment can vary between public health authorities, which can contribute to uncertainty among healthcare workers. Knowledge is limited and reports of experiences are essential.There is a lack of direct information on experience, attitudes and the infection prevention of healthcare workers. Elicitations of health system worker´s experience, attitudes and personal protection of the use of masks, hygiene measures and vaccinations are required. The aim of this study is to determine the protection situation of general practitioners and employees of nursing homes. The knowledge and the experiences of practitioner´s protection help to uncover strengths and weaknesses and for guiding evidence-based protective measures in healthcare settings. Method: This mixed-method study will examine the protection situation of general practitioners and employees of nursing homes by executing semi-structured interviews and a survey.

Publicationslinked via Europe PMC

Last Updated:41 minutes ago

View all publications at Europe PMC

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.

A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections.

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.

Proximity labeling approaches to study protein complexes during virus infection.