Collaborative project: Theranostic concepts for the diagnosis and treatment of hyperinflammation syndrome - Subproject: Synthesis and effect analysis of theranostics in inflammatory disease models

About 15% of patients infected with the newly identified SARS-CoV-2 virus develop a critical form of the disease characterized by respiratory and/or multi-organ failure due to hyperinflammation as an overreaction of the innate nonspecific immune system against the unknown pathogen. The experiments and models described in our HYPERFLAME proposal will provide valuable insights in this context and pave the way for the possible development of an innovative approach to effectively and early detect, monitor and treat hyperinflammation syndrome. The aim of subproject 1 "Synthesis and effect analysis of theranostics in inflammatory disease models" of the HYPERFLAME joint project is to build a chemical platform with functionalized dendritic polymers for the development of active substances for therapy and diagnosis (theranostics) of hyperinflammatory syndrome in virus-related infections and autoimmune diseases. This represents an innovation in this field and will also lead to improved tools for preclinical and clinical research.