Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn (CICERO)
- Funded by Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR)
- Total publications:10 publications
Grant number: COV-LT2-0014
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Key facts
Disease
COVID-19Start & end year
20212024Known Financial Commitments (USD)
$1,801,884Funder
Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR)Principal Investigator
N/A
Research Location
United KingdomLead Research Institution
University College LondonResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Post acute and long term health consequences
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Cognitive impairment is increasingly recognised as a major component of long Covid, estimated to be present in 25-75% of affected individuals. This impairment impacts quality of life and the loss of functional ability has major consequences for affected people, their families and the wider economy given people s difficulty in returning to work. We propose a two-stage study for investigation and treatment of "cognitive Covid". Stage 1 will determine those aspects of cognitive function that are particularly affected in cognitive Covid and the severity of the impairment. We will also explore the relationship between cognitive impairment and other aspects of long Covid, namely fatigue, anxiety, depression and sleep disturbance. MRI scanning will be used to measure brain structure and connectivity, to identify the brain networks affected in cognitive Covid that may underpin the cognitive dysfunction. Stage 2 will focus on helping people recover from cognitive Covid. This will involve use of rehabilitation strategies aimed at improving function in those cognitive functions identified in Stage 1 as being most affected, and assessing the benefit of rehabilitation on quality of life and people s ability to return to everyday function. These strategies will be co-produced in collaboration with a group of people living with cognitive Covid. At the end of Stage 2 we will produce a freely available "Covid- 19 Cognitive Recovery Guide" for affected people, their close contacts and clinicians. In conclusion, cognitive impairment is frequently observed in long Covid but at present little is understood about its nature, or how it can be treated. The sheer scale of the CV19 pandemic makes this a top priority unmet need for healthcare worldwide. The aim of this study is to meet this need and to deliver a treatment plan for affected people which will help them return to normal life and working ability.
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