COVIGRO: Impact of COVID-19 and the SARS-CoV-2 vaccine on placental and fetal development

The scientific data on the impact of COVID-19 on pregnancy are limited but suggest an increase in complications such as preterm birth and preeclampsia. At the same time, the scientific data are limited regarding the effectiveness of the COVID-19 vaccine given during pregnancy and whether gestational age can influence its effectiveness and/or impact on the outcome of the pregnancy. We will compare two cohorts of pregnant women, one recruited before the pandemic (2017-2018) and one recruited during the 2020-2021 pandemic. Using blood tests collected at different times during pregnancy, and using questionnaires, we will be able to establish whether the patient was infected with COVID-19 and whether she received the vaccine. We will evaluate the effect of COVID-19 on placental development and fetal development, as well as on the rate of complications. Finally, we will evaluate whether the vaccine received during pregnancy is as effective as the vaccine received before or after pregnancy.