MP: Aminoacridines with dual SARS-CoV2 antiviral and immunostimulating activity

A group of chemical substances which regulate and which can potentially improve anti-viral immune responses in Covid-19 infection were investigated. In addition, the substances had a direct inhibitory effect on the SARS-Cov2 virus in the test system in the laboratory and based on the characterization of these effects, three drug candidates were formulated for injection and tested for tolerance in animal experiments. A candidate is then selected and the project investigated the effect of this drug candidate with a combined stimulating effect on the immune system and inhibitory effect on the SARS-CoV2 virus in a Covid-19 animal model in hamsters. The studies showed that treatment with the drug candidate leads to a milder clinical course of the disease, somewhat less inflammation in the lungs and somewhat better immune responses, but the effects were not so clear that we have so far been able to convince anyone to invest in further development of a drug candidate. The project has therefore been put on hold and the patent application has not been continued.