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Harnessing the beneficial off-target effects of BCG vaccination to boost protection against SARS-CoV-2

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA216978

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2022
    2025

  • Known Financial Commitments (USD)

    $870,639.49

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    N/A

  • Research Location

    Australia

  • Lead Research Institution

    Murdoch Childrens Research Institute

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Bacillus Calmetteâ€"Guérin(BCG), the vaccine that protects against tuberculosis, also protects against other diseases. This is thought to be because BCG can boost immunity. We will investigate how BCG boosts immune responses to SARS-CoV-2 and if this improves protection against COVID-19 and the effectiveness of COVID-19 vaccines. We will combine use of mouse models with use of samples from BRACE, our 6800 participant trial testing if BCG vaccination protects against COVID-19 in healthcare workers.