Restriction of SARS-CoV-2 replication by coding and non-coding genes in human and bat cells
- Funded by Institut Pasteur International Network (IPIN)
- Total publications:14 publications
Grant number: 155686
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Key facts
Disease
COVID-19start year
2021Funder
Institut Pasteur International Network (IPIN)Principal Investigator
Nolwenn JouvenetResearch Location
N/ALead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
About Knowledge concerning the interaction of SARS-CoV-2 with human and bat cells is sparse. We will use state-of-the-art RNA-sequencing analysis, original bioinformatics tools, loss-of-function approaches and mechanistic studies to identify and characterize coding and non-coding genes that restrict viral replication in human and bat cells. Taking advantage of some of these naturally occurring viral inhibitors may be an effective strategy in the development of novel drugs to treat the disease.
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