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Identification of cellular PDZ-containing Proteins targeted by the SARS-Cov-2 virus during infection (PPCOVi)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: 144475

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Key facts

  • Disease

    COVID-19

  • start year

    2020

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    Nicolas Wolff

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

About Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular proteins that would be targeted by these viral proteins during infection and to characterize the mechanism by which viral sequences compete with cellular interactions through PDZ domains.