Return to homepagePandemic Pact

Study of immune crosstalk in COVID-19 COVIMUNE

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: 146675

Grant search

Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2021

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    Anavaj Sakuntabhai

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

About Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 viruses in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target the priority of "pathophysiology of the disease" through the following objectives 1. To develop a cellular model to study human-viral interactions on the adaptive immune response 2. To dissect of how antigen-presenting cells (APCs) polarize T cell responses leading to over-reactive immunological reaction and/or protective memory T cells 3. To investigate the role of regulatory T cell (Treg) in regulating immune responses 4. To identify CD4+ T cell epitopes of SARS-CoV-2 presented by APCs and validation of these epitopes in patients recovered from COVID-19 5. To explore underlying immune mechanisms predisposing patients with diabetes and cardiovascular diseases to severe COVID-19