Mouse models for Covid-19
- Funded by Institut Pasteur International Network (IPIN)
- Total publications:0 publications
Grant number: 168123
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Key facts
Disease
COVID-19start year
2021Funder
Institut Pasteur International Network (IPIN)Principal Investigator
Xavier MontagutelliResearch Location
N/ALead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Disease models
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
About Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the lungs of standard mice. We are using genetically diverse Collaborative Cross mouse strains to produce a variety of models differing in illness severity. We have also shown that mice are susceptible to several variants of concern (VOCs) which have spread in humans over large geographic areas, raising the possibility of secondary wild rodents reservoirs