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Role of inflammatory mediators as predicting factors of COVID-19 pulmonary disease

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: 177040

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2022

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    Lhousseine Touqui

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Unspecified

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

About Covid-19 disease is characterized by dysregulated immune response leading to enhanced levels of circulating and lung inflammatory mediators. The latter include cytokines and lipid mediators (LMs) which results from increased phospholipid metabolism. The role of cytokines has been extensively examined but the implication of LMs has received little attention. Alteration of phospholipid metabolism is also associated with a number of pathophysiological processes including hydrolysis of pulmonary surfactant phospholipids and cell death or apoptosis. In the present work we examined in airways aspirates of patients with Covid-19 after their admission to ICU, the changes in the levels of LMs and their possible role in the severity of pulmonary disease of these patients.