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COVID-19 vaccination and (short-term) mortality - a self-controlled case series study

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.04303E+13

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2023
    2024

  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)

  • Principal Investigator

    dr. PCJL Bruijning-Verhagen MD PhD

  • Research Location

    N/A

  • Lead Research Institution

    Universitair Medisch Centrum Utrecht

  • Research Priority Alignment

    N/A

  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    Adverse events associated with immunization

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The higher-than-expected death rates during the pandemic remain - at least partly - unexplained. In this study we want to further clarify the role of COVID-19 vaccination in the observed excess mortality. Previous analyses, based on Cox regression, failed to demonstrate a causal role of COVID-19 vaccination, but could not rule out the possibility that the results could be biased by prognostic differences between vaccinated and unvaccinated people. We therefore propose to apply a recently developed method based on a 'self-controlled case series'. This method is specifically designed to quantify short-term mortality after COVID-19 vaccination. Furthermore, it is possible to compare short-term mortality risks between subgroups. The results of this study will provide a better understanding of the risks of COVID-19 vaccination, which will be important for future vaccination strategies.