A Fibrosis Lung-Chip model to study development and therapy of COVID-19 post-ARDS pulmonary fibrosis
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.04301E+13
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Key facts
Disease
COVID-19Start & end year
20232025Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
dr AM. van der Does PhDResearch Location
NetherlandsLead Research Institution
Leids Universitair Medisch CentrumResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Disease models
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The development of severe COVID-19 is associated with significant lung damage, in which connective tissue formation (fibrosis) can be observed in the lung tissue. This only happens in patients with a very serious course of illness, who usually receive mechanical ventilation in intensive care. In addition to the viral infection, mechanical ventilation may also be a risk factor for fibrosis development.