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A Fibrosis Lung-Chip model to study development and therapy of COVID-19 post-ARDS pulmonary fibrosis

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.04301E+13

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2023
    2025

  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)

  • Principal Investigator

    dr AM. van der Does PhD

  • Research Location

    Netherlands

  • Lead Research Institution

    Leids Universitair Medisch Centrum

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Disease models

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The development of severe COVID-19 is associated with significant lung damage, in which connective tissue formation (fibrosis) can be observed in the lung tissue. This only happens in patients with a very serious course of illness, who usually receive mechanical ventilation in intensive care. In addition to the viral infection, mechanical ventilation may also be a risk factor for fibrosis development.