BREAK COVID: COVID-19 breakthrough infections and correlates of protection
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.04301E+13
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Key facts
Disease
COVID-19Start & end year
20232023Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
dr. EDL SchmidtResearch Location
NetherlandsLead Research Institution
Leids Universitair Medisch CentrumResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Prognostic factors for disease severity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
BREAK COVID: breakthrough infections and correlates of protection At this stage of the pandemic, almost everyone has built up immunity against SARS-CoV-2. However, breakthrough infections are often seen after vaccination or natural infection. Breakthrough infections can be contagious, pose a risk to vulnerable people and can also lead to long-term complaints (post-COVID). In particular, the cellular defense could play an important role against breakthrough infections with virus variants. LUMC researchers will study which parts of the defense offer protection against breakthrough infections. More than 40 cellular immune markers will be measured in individuals with and without breakthrough infections. The aim is to identify 3-5 key markers that are predictive of protection against breakthrough infections. The findings will contribute to estimates of the risks of breakthrough infections in the Dutch population and can be used to optimally design the vaccination policy.