Acute lower respiratory tract infection in primary care: improving prognosis by considering the interplay between the lung and the heart

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:5 publications

Grant number: 08391052110003

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2022
    2026
  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)
  • Principal Investigator

    dr TN. Platteel
  • Research Location

    N/A
  • Lead Research Institution

    Universitair Medisch Centrum Utrecht
  • Research Priority Alignment

    N/A
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Acute lower respiratory infections: is there more between the lung and heart? Lower respiratory infections (LRTI), such as pneumonia, are common in adults. Some patients with LRTI require hospitalization. Observations from practice show that this mainly occurs in patients with underlying cardiovascular disease (CVD). The GP does not take this much into account, because the interplay between heart and lung is not yet sufficiently clear. We want to increase knowledge about this interplay by investigating: what are the predictors for the development of additional CVD or worsening of known CVD how additional CVD adversely affects the course of an LRTI whether blood tests of immune response say something about how an LRTI progresses with COVID-19 and without COVID-19, both in the short and long term With this research, the treatment of LRTI can be greatly improved and unknown heart disease can be detected at an early stage.

Publicationslinked via Europe PMC

Prognostic factors and prediction models for hospitalisation and all-cause mortality in adults presenting to primary care with a lower respiratory tract infection: a systematic review.

Predicting adverse outcomes in adults with a community-acquired lower respiratory tract infection: a protocol for the development and validation of two prediction models for (i) all-cause hospitalisation and mortality and (ii) cardiovascular outcomes.

Incomplete and possibly selective recording of signs, symptoms, and measurements in free text fields of primary care electronic health records of adults with lower respiratory tract infections.

Estimated causal effects of common respiratory infections on cardiovascular risk: a meta-analysis.

Incidence and individual risk prediction of post-COVID-19 cardiovascular disease in the general population: a multivariable prediction model development and validation study.