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VeCosCO:Neurobiological basis of long-term cognitive complaints and fatigue after COVID-19

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:6 publications

Grant number: 10430302110003

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2021
    2024

  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)

  • Principal Investigator

    dr. N Tolboom MD PhD

  • Research Location

    N/A

  • Lead Research Institution

    Amsterdam UMC Locatie VUmc

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Post acute and long term health consequences

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Long-term fatigue and cognitive complaints are common problems after a SARS-CoV-2 infection. These complaints have a major impact on daily life. So far, little is known about the course and treatment options. Goal The first goal of this research is to map the long-term fatigue and cognitive complaints of people after experiencing SARS-CoV-2. The second goal is to use imaging techniques (the PET scan and the MRI scan) to gain insight into any underlying pathophysiological processes in these long-term complaints. Background By obtaining more information about the course of long-term fatigue and cognitive complaints, care for people with these complaints can be improved. There are also strong indications that the presence of inflammatory cells in the brain plays a role in long-term fatigue and cognitive complaints. By investigating this further, new insights may be gained for possible treatments. Research design People with long-term fatigue and cognitive complaints are initially mainly recruited from existing SARS-CoV-2 research cohorts. They are extensively investigated and prosecuted in due course. In addition, additional imaging tests are performed on some of these people (the so-called TSPO PET scan with which we look at inflammatory cells in the brain and functional MRI).

6 Publications linked via Europe PMC

Last Updated:a day ago

View all publications at Europe PMC

Post-acute sequelae of COVID-19 (PASC) are associated with distinct clinical phenotypes two years after SARS-CoV-2 infection: A data-driven approach

Long-term cognitive functioning following COVID-19: Negligible neuropsychological changes over time.

Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers.

Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case-control study (VeCosCO).

Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO)

Long COVID is associated with extensive in-vivo neuroinflammation on [ 18 F]DPA-714 PET