VeCosCO:Neurobiological basis of long-term cognitive complaints and fatigue after COVID-19

Long-term fatigue and cognitive complaints are common problems after a SARS-CoV-2 infection. These complaints have a major impact on daily life. So far, little is known about the course and treatment options. Goal The first goal of this research is to map the long-term fatigue and cognitive complaints of people after experiencing SARS-CoV-2. The second goal is to use imaging techniques (the PET scan and the MRI scan) to gain insight into any underlying pathophysiological processes in these long-term complaints. Background By obtaining more information about the course of long-term fatigue and cognitive complaints, care for people with these complaints can be improved. There are also strong indications that the presence of inflammatory cells in the brain plays a role in long-term fatigue and cognitive complaints. By investigating this further, new insights may be gained for possible treatments. Research design People with long-term fatigue and cognitive complaints are initially mainly recruited from existing SARS-CoV-2 research cohorts. They are extensively investigated and prosecuted in due course. In addition, additional imaging tests are performed on some of these people (the so-called TSPO PET scan with which we look at inflammatory cells in the brain and functional MRI).