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Vaccinating children with Long-COVID to improve overall fitness (VINCERE)

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.04301E+13

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2021
    2023

  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)

  • Principal Investigator

    dr MA. van Houten

  • Research Location

    N/A

  • Lead Research Institution

    Spaarne Gasthuis

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Post acute and long term health consequences

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Adolescent (13 years to 17 years)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Not only adults but also many children suffer from long-term complaints after experiencing a COVID-19 infection, such as fatigue and shortness of breath. If these complaints persist for weeks to months, we call it long COVID. Initial reports from adult patients with long COVID show that a vaccination against the coronavirus can improve symptoms. The aim of this study is to evaluate whether this effect also exists in children. Goal Investigate the effect of COVID-19 vaccination in children with long COVID between the ages of 12 and 18. In addition, the differences and similarities in the pattern of complaints and the risk factors for the development of long COVID in children in different age groups are examined. Background Some adults who experience COVID-19 have persistent complaints, called long COVID. These complaints can last for weeks to months. It is unclear what the exact cause of the complaints is, but there are probably several causes. Long COVID can also occur in children, both after severe and mild acute COVID-19 infections. While it appears that some adult patients experience a decrease in long COVID complaints after vaccination, nothing is yet known about a possible positive effect of COVID-19 vaccination in children. Given the impact of this disease on individual functioning and society, it is important that there is more insight into the pathophysiology and possible treatment of long COVID in children. Research design This study examines the effect of a vaccination on fatigue complaints in children aged 12-18 years old who experience complaints for more than 12 weeks. It is examined whether there are differences between children in which the complaints do and do not improve. Because only the Pfizer-BioNTech mRNA vaccine is currently approved for children aged 12 and over, it will be used in the study. The fatigue complaints are analyzed before and after vaccination. In addition to looking at the effect of vaccination, children aged 12-18 years are compared with children aged 6-12 years with long COVID who have not yet been vaccinated to map the pattern of complaints. Executive parties Spaarne Gasthuis, Emma Children's Hospital and Amsterdam UMC.