Vaccination Against Covid in Primary Immune Deficiencies

This study investigates whether patients with an innate immune disorder are protected against COVID-19 after vaccination. Patients with these congenital immune system disorders have an increased risk of developing infections and of a more serious course of infections. They may therefore also be more vulnerable to the serious course of COVID-19. It is therefore important that they are protected. However, it is not yet known how safe and effective the COVID-19 vaccines are in the group. Goal This project examines whether patients with an innate immune disorder actually become protected against COVID-19 after vaccination. Background In patients with congenital disorders, the immune system is less able to fight infections. This makes the risk of infections high. They may therefore also be more vulnerable to a serious course of COVID-19. Protection against COVID-19 through vaccination is therefore crucial for these patients, but due to the reduced immune function, the vaccine may be less effective or provide protection for a shorter period of time. Research design After vaccination, blood is tested at a number of times to see whether protection occurs in the immune system against COVID-19 and whether this protection lasts for a longer period of time. In addition, it will be investigated whether these patients still contract COVID-19 despite vaccination. Expected results Insight into whether corona vaccines work safely and effectively in patients with congenital disorders. This can translate into individualizing the vaccination strategy, including giving additional booster vaccination for those who are insufficiently protected.