sars-COv-2 Vaccination response In people living with HIV - COVIH study

The immune response to corona vaccines is unknown in people living with HIV. As observed with other vaccines, this immune response may be reduced by the immune status of individuals living with HIV. This research studies the immune response to vaccination and identifies the side effects. The course of the immune response will then be studied over the next few years. Goal The aim of this research is to study the immune response to vaccination among people with HIV and to map the side effects. Background Although people living with HIV (PLHIV) can now lead a normal life thanks to HIV inhibitors, their immune system does not always appear to function normally. Previous vaccination studies with, for example, Influenza or Hepatitis vaccines, often showed that the immune response to these vaccines was reduced or even absent. It is unknown how PLHIV respond to the new COVID-19 vaccines. Research design In this study in 22 HIV centers, the antibody responses of PLHIV against the various COVID-19 vaccines will be compared with the responses of people without HIV, 4 weeks after completion of the vaccination. More extensive research is being conducted into, among other things, the cellular immune response in a smaller group of patients. Through the ongoing follow-up via the HIV Monitoring Foundation, the duration of the antibody response and the incidence of new SARS-CoV-2 infections will be analyzed. Expected results The results of the study will be used to provide advice on the use of COVID-19 vaccines in PLHIV.