WikiPathways as a platform for COVID-19 biological pathway models

Key facts

Disease
COVID-19
Start & end year
2020
2024
Funder
Netherlands Organisation for Health Research and Development (ZonMW)
Principal Investigator
dr M. Kutmon
Research Location
Netherlands
Lead Research Institution
Maastricht University
Research Priority Alignment
N/A

Research Category
Health Systems Research
Research Subcategory
Health information systems
Special Interest Tags
Data Management and Data Sharing
Study Type
Not applicable
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

WikiPathways is a globally known and established knowledge platform, founded and maintained by Maastricht University. The platform makes molecular pathway models accessible to researchers, keeps its pathway collection up-to-date and supports the drug development process for the different phases of COVID-19. Research The research has three aspects to help fight COVID-19 and future outbreaks: Expansion of WikiPathways as a source for COVID-19 pathway models. This is done by sharing models and information and collaborating with all COVID-19 research. Improvement of software to better describe virus-human interactions within relevant COVID-19 molecular processes so that computers can use them. The development of analysis procedures using the constant influx of knowledge, experiments and clinical data.

11 Publications linked via Europe PMC

Last Updated:a day ago

View all publications at Europe PMC

Immune digital twins for complex human pathologies: applications, limitations, and challenges.

Authors
Niarakis A, Laubenbacher R, An G, Ilan Y, Fisher J, Flobak Å, Reiche K, Rodríguez Martínez M, Geris L, Ladeira L, Veschini L, Blinov ML, Messina F, Fonseca LL, Ferreira S, Montagud A, Noël V, Marku M, Tsirvouli E, Torres MM, Harris LA, Sego TJ, Cockrell C, Shick AE, Balci H, Salazar A, Rian K, Hemedan AA, Esteban-Medina M, Staumont B, Hernandez-Vargas E, Martis B S, Madrid-Valiente A, Karampelesis P, Sordo Vieira L, Harlapur P, Kulesza A, Nikaein N, Garira W, Malik Sheriff RS, Thakar J, Tran VDT, Carbonell-Caballero J, Safaei S, Valencia A, Zinovyev A, Glazier JA.
Publish Year
2024
Journal
NPJ systems biology and applications
DOI
10.1038/s41540-024-00450-5

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WikiPathways 2024: next generation pathway database.

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.

Authors
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie ME, Funahashi A, Acencio ML, Hemedan A, Aichem M, Klein K, Czauderna T, Burtscher F, Yamada TG, Hiki Y, Hiroi NF, Hu F, Pham N, Ehrhart F, Willighagen EL, Valdeolivas A, Dugourd A, Messina F, Esteban-Medina M, Peña-Chilet M, Rian K, Soliman S, Aghamiri SS, Puniya BL, Naldi A, Helikar T, Singh V, Fernández MF, Bermudez V, Tsirvouli E, Montagud A, Noël V, Ponce-de-Leon M, Maier D, Bauch A, Gyori BM, Bachman JA, Luna A, Piñero J, Furlong LI, Balaur I, Rougny A, Jarosz Y, Overall RW, Phair R, Perfetto L, Matthews L, Rex DAB, Orlic-Milacic M, Gomez LCM, De Meulder B, Ravel JM, Jassal B, Satagopam V, Wu G, Golebiewski M, Gawron P, Calzone L, Beckmann JS, Evelo CT, D'Eustachio P, Schreiber F, Saez-Rodriguez J, Dopazo J, Kuiper M, Valencia A, Wolkenhauer O, Kitano H, Barillot E, Auffray C, Balling R, Schneider R, COVID-19 Disease Map Community.
Publish Year
2023
Journal
Frontiers in immunology
DOI
10.3389/fimmu.2023.1282859

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A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms

Authors
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie ME, Funahashi A, Acencio ML, Hemedan A, Aichem M, Klein K, Czauderna T, Burtscher F, Yamada TG, Hiki Y, Hiroi NF, Hu F, Pham N, Ehrhart F, Willighagen EL, Valdeolivas A, Dugourd A, Messina F, Esteban-Medina M, Peña-Chilet M, Rian K, Soliman S, Aghamiri SS, Puniya BL, Naldi A, Helikar T, Singh V, Fernández MF, Bermudez V, Tsirvouli E, Montagud A, Noël V, de Leon MP, Maier D, Bauch A, Gyori BM, Bachman JA, Luna A, Pinero J, Furlong LI, Balaur I, Rougny A, Jarosz Y, Overall RW, Phair R, Perfetto L, Matthews L, Rex DAB, Orlic-Milacic M, Cristobal MGL, De Meulder B, Ravel JM, Jassal B, Satagopam V, Wu G, Golebiewski M, Gawron P, Calzone L, Beckmann JS, Evelo CT, D’Eustachio P, Schreiber F, Saez-Rodriguez J, Dopazo J, Kuiper M, Valencia A, Wolkenhauer O, Kitano H, Barillot E, Auffray C, Balling R, Schneider R, the COVID-19 Disease Map Community.
Publish Year
2022
DOI
10.1101/2022.12.17.520865

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Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients.

Different B cell activation patterns in asymptomatic and symptomatic COVID-19 patients

COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.

Authors
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, Singh V, Aghamiri SS, Acencio ML, Glaab E, Ruepp A, Fobo G, Montrone C, Brauner B, Frishman G, Monraz Gómez LC, Somers J, Hoch M, Kumar Gupta S, Scheel J, Borlinghaus H, Czauderna T, Schreiber F, Montagud A, Ponce de Leon M, Funahashi A, Hiki Y, Hiroi N, Yamada TG, Dräger A, Renz A, Naveez M, Bocskei Z, Messina F, Börnigen D, Fergusson L, Conti M, Rameil M, Nakonecnij V, Vanhoefer J, Schmiester L, Wang M, Ackerman EE, Shoemaker JE, Zucker J, Oxford K, Teuton J, Kocakaya E, Summak GY, Hanspers K, Kutmon M, Coort S, Eijssen L, Ehrhart F, Rex DAB, Slenter D, Martens M, Pham N, Haw R, Jassal B, Matthews L, Orlic-Milacic M, Senff Ribeiro A, Rothfels K, Shamovsky V, Stephan R, Sevilla C, Varusai T, Ravel JM, Fraser R, Ortseifen V, Marchesi S, Gawron P, Smula E, Heirendt L, Satagopam V, Wu G, Riutta A, Golebiewski M, Owen S, Goble C, Hu X, Overall RW, Maier D, Bauch A, Gyori BM, Bachman JA, Vega C, Grouès V, Vazquez M, Porras P, Licata L, Iannuccelli M, Sacco F, Nesterova A, Yuryev A, de Waard A, Turei D, Luna A, Babur O, Soliman S, Valdeolivas A, Esteban-Medina M, Peña-Chilet M, Rian K, Helikar T, Puniya BL, Modos D, Treveil A, Olbei M, De Meulder B, Ballereau S, Dugourd A, Naldi A, Noël V, Calzone L, Sander C, Demir E, Korcsmaros T, Freeman TC, Augé F, Beckmann JS, Hasenauer J, Wolkenhauer O, Wilighagen EL, Pico AR, Evelo CT, Gillespie ME, Stein LD, Hermjakob H, D'Eustachio P, Saez-Rodriguez J, Dopazo J, Valencia A, Kitano H, Barillot E, Auffray C, Balling R, Schneider R, COVID-19 Disease Map Community.
Publish Year
2021
Journal
Molecular systems biology
DOI
10.15252/msb.202110387

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WikiPathways as a platform for COVID-19 biological pathway models

Key facts

Abstract

11 Publications linked via Europe PMC

Immune digital twins for complex human pathologies: applications, limitations, and challenges.

WikiPathways 2024: next generation pathway database.

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.

A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms

Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients.

Different B cell activation patterns in asymptomatic and symptomatic COVID-19 patients

COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.

Ten simple rules for creating reusable pathway models for computational analysis and visualization.

A protocol for adding knowledge to Wikidata: aligning resources on human coronaviruses.