Identification of the pathogenesis of COVID-19 pathology in the Dutch population and unraveling differences in pathogenetic mechanisms between high- and low-risk groups.

COVID-19 has a striking variation in disease severity between patients. There is currently insufficient knowledge about which processes in the tissue are the cause of this variation. This limits the development of targeted diagnostics and therapy for individual patients. Studying the tissue of COVID-19 patients can change this, because the tissue can distinguish between damage directly caused by the virus, inflammation that has gotten out of hand, increased clotting, and scarring, all of which may require different treatment. Research and expected outcomes In the context of this project, the available and suitable tissue from both deceased and living COVID-19 patients in the Netherlands is being brought together in order to ask and answer these questions. The results are expected to lead to an improved understanding of the variability of this disease and lead to more personalized treatment.