Working together against Corona with Intensive Care Data

Key facts

Disease
COVID-19
Start & end year
2020
2023
Funder
Netherlands Organisation for Health Research and Development (ZonMW)
Principal Investigator
Dr. PWG Elbers
Research Location
N/A
Lead Research Institution
Amsterdam UMC Locatie VUmc
Research Priority Alignment
N/A

Research Category
Clinical characterisation and management
Research Subcategory
Prognostic factors for disease severity
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

Treatment in intensive care appears to be necessary for many COVID-19 patients. It is very important to gain more insight into the disease course of intensive care patients with COVID-19 and the factors that influence this. This can provide direction for the treatment of future patients, help with the choice of who should and should not be treated in intensive care and contribute to future capacity planning. Research The project investigates which combination of treatments and properties of which individual intensive care patients with COVID-19 leads to the best outcomes. This is done using machine learning, an important form of artificial intelligence, which is applied to large amounts of data from intensive care patients with COVID-19 from around 50 collaborating hospitals. The project is supported by the Dutch Association for Intensive Care and the National Intensive Care Evaluation Foundation.

10 Publications linked via Europe PMC

Last Updated:3 days ago

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Reinforcement learning for intensive care medicine: actionable clinical insights from novel approaches to reward shaping and off-policy model evaluation.

Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning.

Authors
Dam TA, Roggeveen LF, van Diggelen F, Fleuren LM, Jagesar AR, Otten M, de Vries HJ, Gommers D, Cremer OL, Bosman RJ, Rigter S, Wils EJ, Frenzel T, Dongelmans DA, de Jong R, Peters MAA, Kamps MJA, Ramnarain D, Nowitzky R, Nooteboom FGCA, de Ruijter W, Urlings-Strop LC, Smit EGM, Mehagnoul-Schipper DJ, Dormans T, de Jager CPC, Hendriks SHA, Achterberg S, Oostdijk E, Reidinga AC, Festen-Spanjer B, Brunnekreef GB, Cornet AD, van den Tempel W, Boelens AD, Koetsier P, Lens J, Faber HJ, Karakus A, Entjes R, de Jong P, Rettig TCD, Arbous S, Vonk SJJ, Machado T, Herter WE, de Grooth HJ, Thoral PJ, Girbes ARJ, Hoogendoorn M, Elbers PWG, Dutch ICU Data Sharing Against COVID-19 Collaborators.
Publish Year
2022
Journal
Annals of intensive care
DOI
10.1186/s13613-022-01070-0

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Evolution of Clinical Phenotypes of COVID-19 Patients During Intensive Care Treatment: An Unsupervised Machine Learning Analysis

Authors
Siepel S, Dam TA, Fleuren LM, Gommers D, Cremer OL, Bosman RJ, Rigter S, Wils E, Frenzel T, Dongelmans DA, de Jong R, Peters M, Kamps MJ, Ramnarain D, Nowitzky R, Nooteboom FG, de Ruijter W, Urlings-Strop LC, Smit EG, Mehagnoul-Schipper DJ, Dormans T, de Jager CP, Hendriks SH, Achterberg S, Oostdijk E, Reidinga AC, Festen-Spanjer B, Brunnekreef GB, Cornet AD, Tempel Wvd, Boelens AD, Koetsier P, Lens J, Faber HJ, Karakus A, Entjes R, de Jong P, Rettig TC, Arbous S, Vonk SJ, Machado T, Herter WE, Girbes AR, Hoogendoorn M, Thoral PJ, Elbers PW, Bennis FC.
Publish Year
2022
DOI
10.21203/rs.3.rs-1328331/v1

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Ethnic Differences in Coronavirus Disease 2019 Hospitalization and Hospital Outcomes in a Multiethnic Population in the Netherlands.

Some Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome.

Authors
Dam TA, de Grooth HJ, Klausch T, Fleuren LM, de Bruin DP, Entjes R, Rettig TCD, Dongelmans DA, Boelens AD, Rigter S, Hendriks SHA, de Jong R, Kamps MJA, Peters M, Karakus A, Gommers D, Ramnarain D, Wils EJ, Achterberg S, Nowitzky R, van den Tempel W, de Jager CPC, Nooteboom FGCA, Oostdijk E, Koetsier P, Cornet AD, Reidinga AC, de Ruijter W, Bosman RJ, Frenzel T, Urlings-Strop LC, de Jong P, Smit EGM, Cremer OL, Mehagnoul-Schipper DJ, Faber HJ, Lens J, Brunnekreef GB, Festen-Spanjer B, Dormans T, Dijkstra A, Simons B, Rijkeboer AA, Arbous S, Aries M, Beukema M, Pretorius D, van Raalte R, van Tellingen M, Gritters van den Oever NC, Lalisang RCA, Tonutti M, Girbes ARJ, Hoogendoorn M, Thoral PJ, Elbers PWG.
Publish Year
2021
Journal
Critical care explorations
DOI
10.1097/cce.0000000000000555

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Systematic Review and Comparison of Publicly Available ICU Data Sets-A Decision Guide for Clinicians and Data Scientists.

Predictors for extubation failure in COVID-19 patients using a machine learning approach.

Authors
Fleuren LM, Dam TA, Tonutti M, de Bruin DP, Lalisang RCA, Gommers D, Cremer OL, Bosman RJ, Rigter S, Wils EJ, Frenzel T, Dongelmans DA, de Jong R, Peters M, Kamps MJA, Ramnarain D, Nowitzky R, Nooteboom FGCA, de Ruijter W, Urlings-Strop LC, Smit EGM, Mehagnoul-Schipper DJ, Dormans T, de Jager CPC, Hendriks SHA, Achterberg S, Oostdijk E, Reidinga AC, Festen-Spanjer B, Brunnekreef GB, Cornet AD, van den Tempel W, Boelens AD, Koetsier P, Lens J, Faber HJ, Karakus A, Entjes R, de Jong P, Rettig TCD, Arbous S, Vonk SJJ, Fornasa M, Machado T, Houwert T, Hovenkamp H, Noorduijn Londono R, Quintarelli D, Scholtemeijer MG, de Beer AA, Cinà G, Kantorik A, de Ruijter T, Herter WE, Beudel M, Girbes ARJ, Hoogendoorn M, Thoral PJ, Elbers PWG, Dutch ICU Data Sharing Against Covid-19 Collaborators.
Publish Year
2021
Journal
Critical care (London, England)
DOI
10.1186/s13054-021-03864-3

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Large-scale ICU data sharing for global collaboration: the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse.

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients.

Authors
Fleuren LM, Dam TA, Tonutti M, de Bruin DP, Lalisang RCA, Gommers D, Cremer OL, Bosman RJ, Rigter S, Wils EJ, Frenzel T, Dongelmans DA, de Jong R, Peters M, Kamps MJA, Ramnarain D, Nowitzky R, Nooteboom FGCA, de Ruijter W, Urlings-Strop LC, Smit EGM, Mehagnoul-Schipper DJ, Dormans T, de Jager CPC, Hendriks SHA, Achterberg S, Oostdijk E, Reidinga AC, Festen-Spanjer B, Brunnekreef GB, Cornet AD, van den Tempel W, Boelens AD, Koetsier P, Lens J, Faber HJ, Karakus A, Entjes R, de Jong P, Rettig TCD, Arbous S, Vonk SJJ, Fornasa M, Machado T, Houwert T, Hovenkamp H, Noorduijn-Londono R, Quintarelli D, Scholtemeijer MG, de Beer AA, Cina G, Beudel M, Herter WE, Girbes ARJ, Hoogendoorn M, Thoral PJ, Elbers PWG.
Publish Year
2021
Journal
Critical care (London, England)
DOI
10.1186/s13054-021-03733-z

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