Monitoring the evolution, spread and transmission of SARS-CoV-2 through whole genome sequencing to enable fast genotype to phenotype prediction

During this project we mapped the evolution and spread of SARS-CoV-2 in the Netherlands. We used this information in different phases of the pandemic: in the first phase we used it to estimate the extent of the pandemic in the Netherlands, then we mapped the evolution of the virus in mink and attempted to control the spread of to contain the virus between mink farms. In the current phase of the pandemic, we are looking at reinfections and viral evolution in patients infected with SARS-CoV-2 for a long time. Collectively, these findings have contributed to increasing our knowledge regarding the course of the pandemic and these results can be used to be better prepared for future variants and a faster translation between the findings in the lab and the possible impact of these findings to decide. Interim results This project has so far delivered the following interim results: - An article about transmission across national borders at the beginning of the COVID-19 pandemic in Limburg. - An article (still under peer review) on tracking SARS-CoV-2 variants B.1.1.7 (British variant) and B.1.351 (South African variant). - An article about the effect of vaccines on SARS-CoV-2 variant B.1.1.7 (British variant) and B.1.351 (South African variant). More information about research into corona and COVID-19 at www.zonmw.nl/coronaonderzoek