An investigation into transmission and total cases of Crimean-Congo haemorrhagic fever (CCHF) in Uganda

Crimean-Congo haemorrhagic fever virus (CCHFV) is endemic in Uganda, shown by high seroprevalence in humans and animals. Sporadic outbreaks are regularly reported in humans in areas considered to be at highest risk within the Ugandan cattle corridor. However, recently we have detected cases of undiagnosed CCHF in patients presenting with acute febrile illness in other parts of the country. The incidence and prevalence of CCHF across Uganda and the extent of the health burden is not known. In this study, we will carry out a country-wide, longitudinal seroprevalence study to assess parts of the country most at risk. We will investigate risk factors using quantitative and qualitative approaches. With a mechanistic mathematical model, I aim to investigate the burden of CCHFV infection in Uganda. This will help to inform policy makers about the burden of CCHF on the health care system and will inform about the need to improve diagnostics for viral infections, thereby reducing misdiagnosis. Additionally, the model can later be used to show the effectiveness of interventions against infection with CCHFV.