Models for risk prediction in complex data structures

Grant number: PRG1197

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2021
    2025
  • Known Financial Commitments (USD)

    $1,186,196.57
  • Funder

    Estonian Research Council
  • Principal Investigator

    Fischer, Krista
  • Research Location

    Estonia
  • Lead Research Institution

    University of Tartu
  • Research Priority Alignment

    N/A
  • Research Category

    Epidemiological studies

  • Research Subcategory

    Disease susceptibility

  • Special Interest Tags

    Data Management and Data Sharing

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The project will join several well-developed research topics in the field of mathematical statistics in Estonia, with a main focus on the methodology for risk prediction. The project is motivated by practical problems from several different fields (genetic epidemiology, infectious disease epidemiology, life and non-life insurance). The problems are mostly related to data structures where the standard statistical methods are not applicable. The main reasons include non-typical distribution (especially in non-life insurance), censoring and truncation (the data on COVID-19 epidemic), as well as dependence between observations in the sample (in the large biobank cohorts). The purpose of the project is to develop methodology for risk prediction for data structures that exhibit such problems. The results will be used in consulting the Government of Estonia in the COVID-19 situation, collaborative projects with the Estonian Biobank and the leading insurance companies in Estonia.

Publicationslinked via Europe PMC

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Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study.

Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank.

Examining the impact of renal dysfunction and diabetes on post-myocardial infarction mortality: insights from a comprehensive retrospective cohort study across different age groups.

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank.

A retrospective cohort study of incidence and risk factors for severe SARS-CoV-2 breakthrough infection among fully vaccinated people.

Lessons learned during the process of reporting individual genomic results to participants of a population-based biobank.

Novel Early Pregnancy Multimarker Screening Test for Preeclampsia Risk Prediction.

Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

The 1st year of the COVID-19 epidemic in Estonia: a population-based nationwide sequential/consecutive cross-sectional study.