H-NMR in solid state and complementary applications

Grant number: PRG1832

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2023
    2027
  • Known Financial Commitments (USD)

    $579,042
  • Funder

    Estonian Research Council
  • Principal Investigator

    Samoson, Ago
  • Research Location

    Estonia
  • Lead Research Institution

    Tallinn University of Technology
  • Research Priority Alignment

    N/A
  • Research Category

    14

  • Research Subcategory

    N/A

  • Special Interest Tags

    Innovation

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

We shall custom-engineer MAS and metabolomics NMR and apply it on selected problems, notably Alzheimer's, Parkinson's, COVID, diabetes and cardiovascular conditions, fluor ion batteries, wood chemistry, also universal AI-assisted diagnostics and monitoring. We shall in particular focus on phytochemicals as the fastest and least harmful option to address acute health issues like SARS infection and neurodegenerative diseases. New hardware, based on fast mechanical spinning up to 15 Million RPM, electron spin polarization transfer (DNP), a sophisticated multi-axes sample rotation (DOR) and also 1.2GHz NMR magnets are expected to provide an unprecedented resolution and sensitivity in NMR, rendering it principally more helpful for a significantly wider range of material sciences and biomedical topics. In complex functional cases, the NMR will be arguably more informative and convenient than presently popular methods of plasmon resonance, CryoEM, X-ray or MS.

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Solid-state NMR backbone chemical shift assignments of α-synuclein amyloid fibrils at fast MAS regime.

Simulation of oriented NMR spectra: Combining molecular dynamics and chemical shift tensor calculations.

High and fast: NMR protein-proton side-chain assignments at 160 kHz and 1.2 GHz.

Sex-dependent expression levels of VAV1 and P2X7 in PBMC of multiple sclerosis patients.