Cambridge ESRC DTP Interdisciplinary Studentship 2021: Early-life and intergenerational effects on later-life outcomes over the long-term

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: 2623123

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Key facts

  • Disease

    Influenza caused by Influenza A virus subtype H1
  • Start & end year

    2021
    2025
  • Known Financial Commitments (USD)

    $0
  • Funder

    UK Research and Innovation (UKRI)
  • Principal Investigator

    N/A

  • Research Location

    United Kingdom
  • Lead Research Institution

    University of Cambridge
  • Research Priority Alignment

    N/A
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)Infants (1 month to 1 year)

  • Vulnerable Population

    Pregnant women

  • Occupations of Interest

    Unspecified

Abstract

My proposed research will explore two main themes, using the two data sources mentioned in the project description. Firstly, I hope to use the detailed Derbyshire Health Visitor records to study the short- and long-term impact of the 1918/1919 influenza epidemic on infants during gestation and the first year of life. I want to identify the general impact of influenza on both pregnant mothers and the infants themselves, and how the timing of the influenza-onset may have impacted its effect. I hope this study can add to the 'positive selection' debate regarding shocks in utero. I will also use the dataset to look at the relationship between infant mortality and the foetal origins thesis. Secondly, I will use the Cambridge Group Family Reconstitution dataset to study infant mortality clustering in England, and intergenerational fertility and mortality rates. Through these ideas, I hope to expand our understanding of the mechanisms through which infant mortality is propagated individually and across populations, and how in utero environments are impacted by exogenous factors. I am particularly interested in how the causes behind health inequality and infant mortality manifest themselves biologically over time, and how to break these cycles.