Cambridge ESRC DTP Interdisciplinary Studentship 2021: Early-life and intergenerational effects on later-life outcomes over the long-term
- Funded by UK Research and Innovation (UKRI)
- Total publications:0 publications
Grant number: 2623123
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Key facts
Disease
Influenza caused by Influenza A virus subtype H1Start & end year
20212025Known Financial Commitments (USD)
$0Funder
UK Research and Innovation (UKRI)Principal Investigator
N/A
Research Location
United KingdomLead Research Institution
University of CambridgeResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Disease pathogenesis
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Adults (18 and older)Infants (1 month to 1 year)
Vulnerable Population
Pregnant women
Occupations of Interest
Unspecified
Abstract
My proposed research will explore two main themes, using the two data sources mentioned in the project description. Firstly, I hope to use the detailed Derbyshire Health Visitor records to study the short- and long-term impact of the 1918/1919 influenza epidemic on infants during gestation and the first year of life. I want to identify the general impact of influenza on both pregnant mothers and the infants themselves, and how the timing of the influenza-onset may have impacted its effect. I hope this study can add to the 'positive selection' debate regarding shocks in utero. I will also use the dataset to look at the relationship between infant mortality and the foetal origins thesis. Secondly, I will use the Cambridge Group Family Reconstitution dataset to study infant mortality clustering in England, and intergenerational fertility and mortality rates. Through these ideas, I hope to expand our understanding of the mechanisms through which infant mortality is propagated individually and across populations, and how in utero environments are impacted by exogenous factors. I am particularly interested in how the causes behind health inequality and infant mortality manifest themselves biologically over time, and how to break these cycles.